We recently investigated the effects of the noradrenergic antidepressant reboxetine and the antipsychotic amisulpride compared to placebo on neural correlates of primary reinforcers by visual erotic stimulation in healthy subjects. Whereas, amisulpride left subjective sexual functions and corresponding neural activations unimpaired, attenuated neural activations were observed under reboxetine within the nucleus accumbens Nacc along with diminished behavioral sexual functioning. However, a global dampening of the reward system under reboxetine seemed not intuitive considering the complementary role of the noradrenergic to the dopamine system in reward-related learning mediated by prediction error processing.
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It is the title track from her fifth studio album Eroticaand was released as the album's lead single on September 29, by Maverick Records. It was later included on her greatest hits albums GHV2 and Celebration The song was written by Madonna, Shep Pettibone and Anthony Shimkin, while production was handled by the singer and Pettibone.